After dealing with the Daxamite Invasion and the loss of Mon-El, Kara becomes a full-time Supergirl until she realizes her life as Kara is important. Afterwards Supergirl joins Martian Manhunter on Mars to save his planet after discovering his father is still alive. Kara investigates a cult based around Rao the Kryptonian deity and claims Supergirl as their savior. The group is formed from the survivors Kara saved as her first outing as Supergirl.
Lena Luthor is framed for poisoning children with lead radiation when she used the Daxamite bomb to defend Earth by Morgan Edge. Both Kara and Samantha Arias find the answers to the frame up and informs Lena who is later kidnapped by Morgan Edge. Supergirl rescues Lena and Samantha discovers she can withstand bullets.
Kara finds Mon-El in a 12,000 year-old ship as Samantha discovers her Kryptonian heritage. Kara discovers Mon-El went into the future and arrived in the 31st century Earth where he got married to Saturn Girl of the Legion of Superheroes. Samantha uses the Kryptonian crystal to build the Fortress of Sanctuary and discovers she is the worldkiller Reign.
After Kryptonian symbols are appearing all over National City, Supergirl confronts Reign who defeats her. Kara is in a coma and Brainiac 5 helps to guide her come back. Meanwhile the Legion of Superheroes assemble to hold off against Reign until Kara arrives to stop her.
Supergirl and Saturn Girl team up with Livewire and Psi on a mission to Fort Rozz to recover a prisoner Rozz who has information on how to defeat Reign. Kara discovers from Rozz that other Worldkillers exist before she is killed by Reign. Livewire and Psi take on Reign to save Supergirl but Livewire is killed. Supergirl returns to Earth trying to find the other Worldkillers before Reign does.
DEO captures the Worldkiller Purity who escapes and attacks the city’s subway tunnel where Supergirl, Mon-El, Alex, and Martian Manhunter attempt to stop her. Reign arrives and takes Purity to find the third Worldkiller Pestilence. J’onn, Winn, and Mon-El band together to fix the Legion ship. We discover the marriage between Mon-El and Saturn Girl was arranged to unite the planets. The Legion's mission was to find the third Worldkiller who will become Blight in the future. Meanwhile Lena Luthor treats Samantha Arias, Reign. The third Worldkiller Pestilence arrives and both Supergirl and Imra team up to stop her. Pestilence reunites with Purity and together rescue Reign from Lena Luthor.
Supergirl, Lena Luthor, and Alex use Brainiac's technology to hack into world of Reign to find Samantha. Together they find the location of the Fortress of Sanctuary with Martian Manhunter and Mon-El joining them to take on the Dark Trinity. Both Pestilence and Purity destroy one another as Purity regains her human consciousness. However the combined powers of both Pestilence and Purity enter into Reign and she escapes as the Sanctuary falls. Now Reign must kill her human side to be complete so she plans on killing Ruby, Samantha's daughter.
Lena Luthor hid Ruby in her brother's mansion which is clocked as her mother Reign searches for her. Reign kills her birth mother and finds Ruby however she is captured by Supergirl and Mon-El using synthesized Kryptonite from Lena Luthor. However Reign is adapting to the Kryptonite thanks to the powers of Pestilence.
Guardian and Supergirl stop the Church of Rao from creating another Worldkiller. They discover a rock called Yuda Kal that could stop Reign so Mon-El and Supergirl must travel 5 Light Years away to get it. They land on a Argo City where Supergirl meets her mom who along with the Argo Council gave the rock Yuda Kal to cure Reign. However the priestess who has been guiding Reign has been on Argo City all along.
Supergirl heads back to Earth with Mon-El and cures Reign with the Yuda Kal. Afterwards Kara Zor-El returns to Argo City to spend time with her mother, as the Daughters of the Night take their ship to Earth and resurrect the Fortress of Sanctuary. The Daughters of the Night resurrect Reign as she turns Earth into New Krypton. Kara, her mother, and Mon-El transport back to Earth to stop them. Kara stops Reign however she inadvertently created a new nemesis by using the Yuda Kal in Siberia: The Red Daughter.
RECOMMENDED – 4 OUT OF 5
